50% NON-RESPONDER RATE: tACS fails in half of subjects (Nature Comms 2019)
Full Description
A major study published in Nature Communications (2019) found that approximately half of all participants in tACS studies do not respond in the expected direction. Some even show REVERSED effects. This is caused by individual differences in brain anatomy (skull thickness, cortical folding), neurophysiology (intrinsic peak frequency), and hormonal state. This means the King's Chamber's electromagnetic pathway (piezoelectric field at ~110Hz) would have been ineffective for roughly half the population based on EM stimulation alone. However, the multi-pathway approach (acoustic + EM + infrasound + tactile) would catch most non-responders through at least one other pathway. The redundancy is the design strength.
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